Clone:
REA1170
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Signal-regulatory protein β-1 (SIRP-β-1), SIRP-BETA-1, CD172 antigen-like family member B

Specifications for CD172b (SIRPβ) Antibody, anti-human, REAfinity™

Overview

Clone REA1170 recognizes the human CD172b antigen, a single-pass type I membrane protein also known as signal-regulatory protein beta (SIRPβ). Signal regulatory proteins (SIRPs) are a family of transmembrane receptor-like signaling proteins that are abundantly expressed in hematopoietic cells, including granulocytes, monocytes, dendritic cells, and lymphocytes. In addition, SIRPs are expressed in neuronal cells and certain types of cancer cells. SIRPs can be divided into two subfamilies, CD172a and CD172b, based on the putative structures of their C-terminal intracellular domains which distinguish them as either activating (CD172b) or inhibitory (CD172a) isoforms. CD172b is expressed on peripheral blood monocytes, dendritic cells, and granulocytes.
Additional information: Clone REA1170 displays negligible binding to Fc receptors.

Alternative names

Signal-regulatory protein β-1 (SIRP-β-1), SIRP-BETA-1, CD172 antigen-like family member B

Detailed product information

Technical specifications

CloneREA1170
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD172b (SIRPβ)
Alternative names of antigenSignal-regulatory protein β-1 (SIRP-β-1), SIRP-BETA-1, CD172 antigen-like family member B
Molecular mass of antigen [kDa]40
Distribution of antigendendritic cells, granulocytes, lymphocytes, monocytes, neural cells, tumor cells
Entrez Gene ID10326
RRIDAB_2784000, AB_2783995, AB_2783994, AB_2784003, AB_2784002, AB_2784005, AB_2784004, AB_2783997, AB_2783996, AB_2784007, AB_2784006, AB_2783999, AB_2783998, AB_2784001

References for CD172b (SIRPβ) Antibody, anti-human, REAfinity™

Publications

  1. Kharitonenkov, A. et al. (1997) A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature 386(6621): 181-186
  2. Dietrich, J. et al. (2000) Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells. J. Immunol. 164(1): 9-12
  3. Liu, Y. et al. (2005) SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration. J. Biol. Chem. 280(43): 36132-36140

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