Clone:
B4B6
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
SIRPB1, SIRP-BETA-1

Specifications for CD172b (SIRPβ) Antibody, anti-human

Overview

Clone B4B6 recognizes the human CD172b antigen, a single-pass type I membrane protein also known as signal-regulatory protein beta (SIRPβ). SIRPs are a family of transmembrane receptor-like signaling proteins that are abundantly expressed in hematopoietic cells, including granulocytes, monocytes, dendritic cells, and lymphocytes. In addition, SIRPs are expressed in neuronal cells and certain types of cancer cells. SIRPs can be divided into two subfamilies, CD172a and CD172b, based on the putative structures of their C-terminal intracellular domains which distinguish them as either activating (CD172b) or inhibitory (CD172a) isoforms. CD172b is expressed on peripheral blood monocytes, dendritic cells, and granulocytes.

Alternative names

SIRPB1, SIRP-BETA-1

Detailed product information

Technical specifications

CloneB4B6
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD172b (SIRPβ)
Alternative names of antigenSIRPB1, SIRP-BETA-1
Molecular mass of antigen [kDa]40
Distribution of antigendendritic cells, monocytes
Entrez Gene ID10326
RRIDAB_2655620, AB_2655621, AB_2655622, AB_2655623, AB_2655624, AB_2655625, AB_2655626, AB_2655627, AB_2655628, AB_2655629, AB_2655630, AB_2655619

References for CD172b (SIRPβ) Antibody, anti-human

Publications

  1. Dietrich, J. et al. (2000) Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells. J. Immunol. 164(1): 9-12
  2. Kharitonenkov, A. et al. (1997) A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature 386(6621): 181-186
  3. Liu, Y. et al. (2005) SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration. J. Biol. Chem. 280(43): 36132-36140

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