Clone:
REA144
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MC
Alternative names:
SIRPα, Bit, Mfr, MYD-1, P84, Ptpns1, SHPS-1, Sirp

Specifications for CD172a (SIRPα) Antibody, anti-human, REAfinity™

Overview

Clone REA144 recognizes CD172a, which is also known as signal regulatory protein α (SIRPα). CD172a belongs to the Ig superfamily and is 75–110 kDa single-pass type I regulatory membrane protein. Expression of CD172a is found primarily on hematopoietic stem cells, neurons, and myeloid cells such as macrophages, monocytes, dendritic cells, granulocytes, and myeloid progenitors. CD172a phosphorylated at intracellular tyrosine sites, in response to extracellular stimuli, serves as the docking site for phosphatases such as SHP-1, SHP-2, or SHIP, which inturn desphosphorylate molecules involved in regulating various physiological effects. CD47 has been suggested as a ligand of CD172a.
Additional information: Clone REA144 displays negligible binding to Fc receptors.

Alternative names

SIRPα, Bit, Mfr, MYD-1, P84, Ptpns1, SHPS-1, Sirp

Detailed product information

Technical specifications

CloneREA144
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD172a (SIRPα)
Alternative names of antigenSIRPα, Bit, Mfr, MYD-1, P84, Ptpns1, SHPS-1, Sirp
Molecular mass of antigen [kDa]52
Distribution of antigenmacrophages, dendritic cells, monocytes, neurons, stem cells, granulocytes, hematopoietic stem and progenitor cells
Entrez Gene ID140885
RRIDAB_2801815, AB_2801813, AB_2811495, AB_2811491, AB_2801909, AB_2655599, AB_2655600, AB_2655601, AB_2655602, AB_2655603, AB_2655604, AB_2655609, AB_2655610

References for CD172a (SIRPα) Antibody, anti-human, REAfinity™

Publications

  1. Motegi, S. et al. (2003) Role of the CD47-SHPS-1 system in regulation of cell migration. EMBO J. 22(11): 2634-2644
  2. Jung, C. J. et al. (2016) Comparative analysis of piggyBac, CRISPR/Cas9 and TALEN mediated BAC transgenesis in the zygote for the generation of humanized SIRPA rats. Sci Rep 6: 31455
  3. Oshima, K. et al. (2002) SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Lett. 519(1-3): 1-7

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