Clone:
555
Type of antibody:
Primary antibodies
Isotype:
rat IgG2a
Applications:
FC, MICS, IF, IHC
Alternative names:
L1CAM, L1, NCAM-L1

Specifications for CD171 (L1CAM) Antibody, anti-mouse

Overview

The monoclonal antibody clone 555 recognizes CD171, a single pass type I membrane glycoprotein belonging to the immunoglobulin superfamily. Also known as L1CAM (L1 cell adhesion molecule) or NCAM-L1, CD171 belongs to a subgroup of cell adhesion molecules, which consists of six Ig-like domains, five fibronectin type III (FNIII)-like domains, a transmembrane region and a cytoplasmic domain. Expression of CD171 is found on tetanus-toxin positive neurons1, endothelial cells, certain epithelial cells, reticular fibroblasts and several malignant tumors including colon and breast carcinomas, colon melanoma, tumor cells of neuronal and mesothelial origin, where a role of CD171 in augmenting tumor growth has been demonstrated. Thus, CD171 is considered a novel marker for carcinoma progression.
CD171 displays binding to a number of ligands including homophilic interaction with itself and heterophilic binding to integrins, other cell adhesion molecules, extracellular matrix molecules and thus plays a vital role in cell adhesion and signal transduction. It is involved in the development of the nervous system and regulates processes such as neuron–neuron adhesion, myelination, axonal guidance, and neuronal migration.

Alternative names

L1CAM, L1, NCAM-L1

Detailed product information

Technical specifications

Clone555
Clonalitymonoclonal
Isotyperat IgG2a
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD171 (L1CAM)
Alternative names of antigenL1CAM, L1, NCAM-L1
Molecular mass of antigen [kDa]139
Distribution of antigenendothelial cells, fibroblasts
Entrez Gene ID16728
RRIDAB_2655589, AB_2655590, AB_2655591, AB_2655592, AB_2655593, AB_2655594, AB_2655595, AB_2655596, AB_2655597, AB_2655598, AB_2727206

Resources for CD171 (L1CAM) Antibody, anti-mouse

References for CD171 (L1CAM) Antibody, anti-mouse

Publications

  1. Rathjen, F. G. et al. (1984) Immunocytological and biochemical characterization of a new neuronal cell surface component (L1 antigen) which is involved in cell adhesion. EMBO J. 3(1): 1-10
  2. Jungblut, M. et al. (2012) Isolation and characterization of living primary astroglial cells using the new GLAST-specific monoclonal antibody ACSA-1. Glia 60(6): 894-907
  3. G. Kantzer, C. et al. (2017) Anti-ACSA-2 defines a novel monoclonal antibody for prospective isolation of living neonatal and adult astrocytes. Glia 65(6): 990-1004
  4. Schaefer, A. W. et al. (1999) Activation of the MAPK signal cascade by the neural cell adhesion molecule L1 requires L1 internalization. J. Biol. Chem. 274: 37965-37973
  5. Batiuk, M. Y. et al. (2017) An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody. J. Biol. Chem. 292(21): 8874-8891
  6. Itoh, K. et al. (2004) Brain development in mice lacking L1–L1 homophilic adhesion. J. Cell Biol. 165: 145-154
  7. Needham, L. K. et al. (2001) Cytoplasmic domain mutations of the L1 cell adhesion molecule reduce L1-ankyrin interactions. J. Neurosci. 21: 1490-1500
  8. Huszar, M. et al. (2006) Expression profile analysis in multiple human tumors identifies L1 (CD171) as a molecular marker for differential diagnosis and targeted therapy. Hum. Pathol. 37(8): 1000-1008

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