Clone:
REA163
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
L1CAM, CAML1, HSAS, MASA, MIC5, N-CAM-L1, S10, SPG1

Specifications for CD171 (L1CAM) Antibody, anti-human, REAfinity™

Overview

Clone REA163 recognizes human CD171, a single-pass type I membrane glycoprotein belonging to the immunoglobulin superfamily. Also known as L1 cell adhesion molecule (L1CAM) or NCAM-L1, CD171 belongs to a subgroup of cell adhesion molecules, which consist of six Ig-like domains, five fibronectin type III (FNIII)-like domains, a transmembrane region, and a cytoplasmic domain. Expression of CD171 is found on tetanus-toxin positive neurons, endothelial cells, certain epithelial cells, reticular fibroblasts, and several malignant tumors including colon and breast carcinomas, colon melanoma, tumor cells of neuronal, and mesothelial origin, where a role of CD171 in augmenting tumor growth has been demonstrated. Thus, CD171 is considered a novel marker for carcinoma progression. CD171 displays binding to a number of ligands including homophilic interaction with itself and heterophilic binding to integrins, other cell adhesion molecules, extracellular matrix molecules. It is involved in the development of the nervous system and regulates processes such as neuron–neuron adhesion, myelination, axonal guidance, and neuronal migration.
Additional information: Clone REA163 displays negligible binding to Fc receptors.

Alternative names

L1CAM, CAML1, HSAS, MASA, MIC5, N-CAM-L1, S10, SPG1

Detailed product information

Technical specifications

CloneREA163
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD171 (L1CAM)
Alternative names of antigenL1CAM, CAML1, HSAS, MASA, MIC5, N-CAM-L1, S10, SPG1
Distribution of antigenneurons, endothelial cells
RRIDAB_2876926, AB_2876927, AB_2876953, AB_2876954, AB_2655581, AB_2655582, AB_2655585, AB_2655586

Resources for CD171 (L1CAM) Antibody, anti-human, REAfinity™

References for CD171 (L1CAM) Antibody, anti-human, REAfinity™

Publications

  1. Rathjen, F. G. et al. (1984) Immunocytological and biochemical characterization of a new neuronal cell surface component (L1 antigen) which is involved in cell adhesion. EMBO J. 3(1): 1-10
  2. Schaefer, A. W. et al. (1999) Activation of the MAPK signal cascade by the neural cell adhesion molecule L1 requires L1 internalization. J. Biol. Chem. 274: 37965-37973
  3. Needham, L. K. et al. (2001) Cytoplasmic domain mutations of the L1 cell adhesion molecule reduce L1-ankyrin interactions. J. Neurosci. 21: 1490-1500
  4. Huszar, M. et al. (2006) Expression profile analysis in multiple human tumors identifies L1 (CD171) as a molecular marker for differential diagnosis and targeted therapy. Hum. Pathol. 37(8): 1000-1008

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