Clone:
REA1176
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC, MC
Alternative names:
Siglec-1, SN, Sialoadhesin

Specifications for CD169 (Siglec-1) Antibody, anti-human, REAfinity™

Overview

Clone REA1176 recognizes the human CD169, also known as siglec-1 or sialoadhesin, which is a type I transmembrane glycoprotein. It is the largest member of the siglec family, which are cell surface lectins that are able to bind to sialic acids and mediate interactions between proteins and carbohydrates. Siglec-1 is mainly expressed on tissue macrophages and dendritic cells and interacts with its counterreceptor on T cells, which has been identified as CD43.
Additional information: Clone REA1176 displays negligible binding to Fc receptors.

Alternative names

Siglec-1, SN, Sialoadhesin

Detailed product information

Technical specifications

CloneREA1176
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD169 (Siglec-1)
Alternative names of antigenSiglec-1, SN, Sialoadhesin
Molecular mass of antigen [kDa]181
Distribution of antigendendritic cells, macrophages
Entrez Gene ID6614
RRIDAB_2783984, AB_2783980, AB_2783979, AB_2783989, AB_2783988, AB_2783991, AB_2783990, AB_2783981, AB_2783987, AB_2783986, AB_2783993, AB_2783992, AB_2783983, AB_2783982, AB_2783985

References for CD169 (Siglec-1) Antibody, anti-human, REAfinity™

Publications

  1. Crocker, P.R. et al. (2001) Siglecs, sialic acids and innate immunity. Trends Immunol. 22(6): 337-342
  2. Hartnell, A. et al. (2001) Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations. Blood 97: 288-296
  3. van den Berg, T. K. et al. (2001) Cutting Edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor Sialoadhesin (Siglec-1). J. Immunol. 166(6): 3637-3640

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