Clone:
REA669
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
BY55

Specifications for CD160 Antibody, anti-mouse, REAfinity™

Overview

Clone REA669 recognizes the mouse CD160 antigen, which is also known as BY55. CD160 is a 27 kDa glycoprotein which is expressed at the cell surface as a tightly disulfide-linked multimer. It binds both classical and non-classical MHC class I molecules. CD160 is a ligand for HVEM (herpes virus entry mediator), which attenuates TCR-mediated signaling. Furthermore it enhances proliferation of activated CD8
+
T cells and regulates NK cell activation.
Additional information: Clone REA669 displays negligible binding to Fc receptors.

Alternative names

BY55

Detailed product information

Technical specifications

CloneREA669
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD160
Alternative names of antigenBY55
Molecular mass of antigen [kDa]58
Distribution of antigenT cells, NK cells
Entrez Gene ID12478
RRIDAB_2655433, AB_2655434, AB_2655435, AB_2655436, AB_2655437, AB_2655438, AB_2655439, AB_2655440, AB_2655441, AB_2655432

References for CD160 Antibody, anti-mouse, REAfinity™

Publications

  1. Anumanthan, A. et al. (1998) Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. J. Immunol. 161(6): 2780-2790
  2. Tsujimura, K. et al. (2006)
    Characterization of murine CD160
    +
    CD8
    +
    T lymphocytes.
    Immunol. Lett. 106(1): 48-56
  3. Cai, G. et al. (2009) The CD160, BTLA, LIGHT/HVEM pathway: a bidirectional switch regulating T-cell activation. Immunol. Rev. 229(1): 244-258

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