Clone:
REA1161
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
KLRC1, NKG2A

Specifications for CD159a (NKG2A) Antibody, anti-mouse, REAfinity™

Overview

Clone REA1161 recognizes the CD159a (NKG2A) antigen, an inhibitory natural killer (NK) cell receptor. CD159a forms heterodimer with CD94 and contains a C-type lectin ectodomain. Inhibitory signal is transmitted by the heterodimer via immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and upon ligand engagement, ITIMs are phosphorylated and transmit signal through docking of various tyrosine phosphatases. CD159a/CD94 binds non-classical MHC class I protein, HLA-E. Expression of CD159a is found mainly on NK cells, NKT cells, and on subsets of CD8
+
cells.
Additional information: Clone REA1161 displays negligible binding to Fc receptors.

Alternative names

KLRC1, NKG2A

Detailed product information

Technical specifications

CloneREA1161
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD159a (NKG2A)
Alternative names of antigenKLRC1, NKG2A
Molecular mass of antigen [kDa]28
Distribution of antigenNK cells, NKT cells, CD8+ T cells
Entrez Gene ID16641
RRIDAB_2752066, AB_2752063, AB_2752067, AB_2752064, AB_2752068, AB_2752065

References for CD159a (NKG2A) Antibody, anti-mouse, REAfinity™

Publications

  1. Vance, R. E. et al. (1998) Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b). J. Exp. Med. 188(10): 1841-1848
  2. Vance, R. E. et al. (2002) Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation. Proc. Natl. Acad. Sci. U.S.A. 99(2): 868-873
  3. Rapaport, A. S. et al. (2015)
    The inhibitory receptor NKG2A sustains virus-specific CD8
    +
    T cells in response to a lethal poxvirus infection.
    Immunity 43(6): 1112-1124

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