Clone:
REA970
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MC
Alternative names:
KIR3DL1, KIR3DL2

Specifications for CD158e/k (KIR3DL1/DL2) Antibody, anti-human, REAfinity™

Overview

Clone REA970 recognizes the human CD158e (KIR3DL1) and CD158k (KIR3DL2) antigens, members of the killer immunoglobulin-like receptor (KIR) family which recognizes subsets of HLA alleles. The family of KIR contributes to the regulation of NK cell–mediated cytotoxicity. Expression is found mainly on CD56
dim
CD16
+
natural killer (NK) cells but also on a subset of CD8
+
T cells. They are monomeric receptors possessing high allelic polymorphism with either two or three Ig-like extracellular domains. According to the length of their cytoplasmic tail, KIRs can be subdivided in inhibitory KIRs and activating KIRs.
Additional information: Clone REA970 displays negligible binding to Fc receptors.

Alternative names

KIR3DL1, KIR3DL2

Detailed product information

Technical specifications

CloneREA970
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD158e/k (KIR3DL1/DL2)
Alternative names of antigenKIR3DL1, KIR3DL2
Distribution of antigenT cells, CD8+ T cells
Entrez Gene ID3811
RRIDAB_2727383, AB_2727447, AB_2727384, AB_2727448, AB_2727385, AB_2727450, AB_2727388, AB_2727449, AB_2727386, AB_2727387, AB_2727445, AB_2727382, AB_2727446

Resources for CD158e/k (KIR3DL1/DL2) Antibody, anti-human, REAfinity™

Documents and Protocols

App notes/customer reports

Cross-reactivity of KIR antibodies

References for CD158e/k (KIR3DL1/DL2) Antibody, anti-human, REAfinity™

Publications

  1. Yawata, M. et al. (2002) Variation within the human killer cell immunoglobulin-like receptor (KIR) gene family. Crit. Rev. Immunol. 22(5–6): 463-482
  2. Uhrberg, M. (2005) The KIR gene family: life in the fast lane of evolution. Eur. J. Immunol. 35(1): 10-15

Related products for
CD158e/k (KIR3DL1/DL2) Antibody, anti-human, REAfinity™

2 products available