Clone:
REA1006
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MC
Alternative names:
KIR2DL2, KIR2DL3, KIR2DS2

Specifications for CD158b (KIR2DL2/DL3) Antibody, anti-human, REAfinity™

Overview

Clone REA1006 recognizes the human CD158b1 (KIR2DL2), CD158b2 (KIR2DL3), and CD158j (KIR2DS2) antigens, members of the killer immunoglobulin-like receptor (KIR) family expressed on natural killer (NK) cells and subsets of T cells.
KIRs contribute to the regulation of NK cell–mediated cytotoxicity and possess high allelic polymorphism with either 2 or 3 Ig-like extracellular domains. According to the length of their cytoplasmic tail, KIRs can be further subdivided in inhibitory KIRs (KIR2DL or KIR3DL) and activating KIRs (KIR2DS or KIR3DS). CD158b provides an inhibitory signal on NK cell lytic activity upon interaction with HLA C (e.g. alleles HLA-Cw1, HLA-Cw3, HLA-Cw7) in an antigen-independent manner.
Additional information: Clone REA1006 displays negligible binding to Fc receptors.

Alternative names

KIR2DL2, KIR2DL3, KIR2DS2

Detailed product information

Technical specifications

CloneREA1006
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD158b (KIR2DL2/DL3)
Alternative names of antigenKIR2DL2, KIR2DL3, KIR2DS2
Molecular mass of antigen [kDa]36
Distribution of antigenNK cells, T cells
Entrez Gene ID3803, 3804
RRIDAB_2727782, AB_2727709, AB_2727783, AB_2727710, AB_2727711, AB_2727784, AB_2727712, AB_2727785, AB_2727713, AB_2819419

Resources for CD158b (KIR2DL2/DL3) Antibody, anti-human, REAfinity™

Documents and Protocols

References for CD158b (KIR2DL2/DL3) Antibody, anti-human, REAfinity™

Publications

  1. Selvakumar, A. et al. (1997) Polymorphism and domain variability of human killer cell inhibitory receptors. Immunol. Rev. 155: 183-196
  2. Farag, S. S. et al. (2002) Natural killer cell receptors: new biology and insights into the graft-versus-leukaemia effect. Blood 100(6): 1935-1947
  3. Hsu, K. et al. (2002) The killer cell immunoglobin-like (KIR) genomic region: gene-order, haplotypes and allelic polymorphism. Immunol. Rev. 190: 40-52

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