Clone:
REA1081
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
PVR, PVS, NECL-5, TAGE4

Specifications for CD155 Antibody, anti-human, REAfinity™

Overview

Clone REA1081 recognizes the human CD155 antigen, a single-pass type I membrane protein also known as poliovirus receptor (PVR) or nectin-like protein 5 (NECL-5). CD155 is composed of two Ig-like C2-type domains and one Ig-like V-type domain that is necessary for poliovirus binding and uptake. Four different isotypes (α to δ) exist, originated from alternate splicing of the CD155 mRNA. CD155 is a broadly expressed receptor which is found on, for example, monocytes, a T cell subset, and neurons of the central nervous system. CD155 is also expressed on some CD34
+
progenitor cells, particulary on progenitors committed in myeloid differentiation. It can interact with several ligands, such as CD226, TIGIT, CD96, vitronectin, integrin αvβ3, and PDGFR. The functions of CD155 include roles in cell adhesion, neural differentiation, and NK cell effector functions.
Additional information: Clone REA1081 displays negligible binding to Fc receptors.

Alternative names

PVR, PVS, NECL-5, TAGE4

Detailed product information

Technical specifications

CloneREA1081
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD155
Alternative names of antigenPVR, PVS, NECL-5, TAGE4
Molecular mass of antigen [kDa]43
Distribution of antigenmonocytes, T cells, CNS cells
Entrez Gene ID5817
RRIDAB_2733617, AB_2733769, AB_2733770, AB_2733343, AB_2733344, AB_2732960, AB_2732961, AB_2733202, AB_2733203, AB_2733096, AB_2733097, AB_2734004, AB_2734005, AB_2733616

References for CD155 Antibody, anti-human, REAfinity™

Publications

  1. Mendelsohn, C. L. et al. (1989) Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily. Cell 56(5): 855 -865
  2. Lozano, E. et al. (2013) The CD226/CD155 interaction regulates the proinflammatory (Tʜ1/Tʜ17)/anti-inflammatory (Tʜ2) balance in humans. J. Immunol. 191(7): 3673-3680