Clone:
RM153
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
rat IgG2bκ
Applications:
FA, FC
Alternative names:
TNFSF8, CD30LG, CD30L

Specifications for CD153 Antibody, anti-mouse

Overview

The monoclonal antibody RM153 reacts with mouse CD153 (CD30 ligand), a 40 kDa type II membrane protein belonging to the NGF/TNF superfamily. It is expressed by activated CD4
+
and CD8
+
T cells. The interaction between CD30 and CD153 enhance the proliferation of stimulated T cells. In the presence of the RM153 antibody this effect is blocked.
In vivo
treatment with this antibody is reported to inhibit or delay immune reactions.

Alternative names

TNFSF8, CD30LG, CD30L

Detailed product information

Technical specifications

CloneRM153
Clonalitymonoclonal
Isotyperat IgG2bκ
Isotype controlIsotype Control Antibody, rat IgG2b
Hostrat
Type of antibodyPrimary antibodies, Functional-grade antibodies
Speciesmouse
AntigenCD153
Alternative names of antigenTNFSF8, CD30LG, CD30L
Molecular mass of antigen [kDa]27
Distribution of antigenB cells, granulocytes, macrophages, monocytes, eosinophils, neutrophils, bone marrow
Entrez Gene ID21949
RRIDAB_2655256, AB_2655257, AB_2655258, AB_2655255

References for CD153 Antibody, anti-mouse

Publications

  1. Akiba, H. et al. (1999) CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. J. Immunol. 162(12): 7058-7066
  2. Kjaergaard, J. et al. (2001) Augmentation versus inhibition: effects of conjunctional OX-40 receptor monoclonal antibody and IL-2 treatment on adoptive immunotherapy of advanced tumor. J. Immunol. 167: 6669-6677
  3. al-Shamkhani, A. et al. (1996) OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand. Eur. J. Immunol. 26(8): 1695-1699

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