Clone:
REA265
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24

Specifications for CD151 Antibody, anti-human, REAfinity™

Overview

Clone REA265 recognizes the CD151 antigen, a 29 kDa cell surface glycoprotein, which is also known as platelet-endothelial tetraspan antigen 3 (PETA-3) or tetraspanin-24 (Tspan-24). Like other tetraspanin family members, CD151 contains four hydrophobic transmembrane domains, two short cytoplasmic tails, and one small and one large extracellular loop. CD151 is expressed by many different cell types such as platelets, immature hematopoietic cells, megakaryocytes, keratinocytes, epithelial cells, muscle cells, Schwann cells, vascular endothelium, as well as epithelial cells. It complexes with integrins and other transmembrane 4 superfamily proteins and is involved in cellular processes including cell adhesion and regulates integrin trafficking and function. CD151 enhances cell motility, invasion, and metastasis of tumor cells.
Additional information: Clone REA265 displays negligible binding to Fc receptors.

Alternative names

GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24

Detailed product information

Technical specifications

CloneREA265
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD151
Alternative names of antigenGP27, MER2, PETA-3, RAPH, SFA1, TSPAN24
Molecular mass of antigen [kDa]28
Distribution of antigenepithelial cells, platelets, keratinocytes, Schwann cells
Entrez Gene ID977
RRIDAB_2655231, AB_2655232, AB_2655233, AB_2655234, AB_2655235, AB_2655236, AB_2655237, AB_2655230

References for CD151 Antibody, anti-human, REAfinity™

Publications

  1. Karamatic, C. V. et al. (2004) CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin. Blood 104(8): 2217-2223
  2. Kohno, M. et al. (2002) CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase. Int. J. Cancer 97(3): 336-343
  3. Chernousov, M. A. et al. (2013) Tetraspanins are involved in Schwann cell-axon interaction. J. Neurosci. Res. 91(11): 1419-1428

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