Clone:
REA299
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IHC, IF
Alternative names:
SLAMF1, CDw150, ESTM51, IPO-3, SLAM

Specifications for CD150 (SLAM) Antibody, anti-mouse, REAfinity™

Overview

Clone REA299 recognizes the mouse CD150 antigen, a 75-95 kD single-pass type I membrane protein also known as signaling lymphocyte activation molecule (SLAM). CD150 belongs to the immunoglobulin superfamily and acts as a self ligand. Expression of CD150 is found on B cells, dendritic cells and activated/memory T cells. It is involved in functions such as stimulation, proliferation and inhibition of apoptosis of B cells, stimulation and IFN-γ production in Th1 T-cell clones and recently it has been identified as the second receptor for measles virus. In combination with CD48 and CD244, CD150 is a useful marker for hematopoietic stem cell studies.
Additional information: Clone REA299 displays negligible binding to Fc receptors.

Alternative names

SLAMF1, CDw150, ESTM51, IPO-3, SLAM

Detailed product information

Technical specifications

CloneREA299
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD150 (SLAM)
Alternative names of antigenSLAMF1, CDw150, ESTM51, IPO-3, SLAM
Molecular mass of antigen [kDa]35
Distribution of antigenB cells, dendritic cells, T cells, stem cells, hematopoietic stem and progenitor cells
Entrez Gene ID27218
RRIDAB_2857823

Resources for CD150 (SLAM) Antibody, anti-mouse, REAfinity™

Documents and Protocols

References for CD150 (SLAM) Antibody, anti-mouse, REAfinity™

Publications

  1. Bleharski, J. R. et al. (2001) Signaling lymphocytic activation molecule is expressed on CD40 ligand-activated dendritic cells and directly augments production of inflammatory cytokines. J. Immunol. 167(6): 3167-3181
  2. Castro, A. G. et al. (1999) Molecular and functional characterization of mouse signaling lymphocytic activation molecule (SLAM): differential expression and responsiveness in Tʜ1 and Tʜ2 cells. J. Immunol. 163(11): 5860-5870
  3. Wang, N. et al. (2004) The cell surface receptor SLAM controls T cell and macrophage functions. J. Immunol. 199(9): 1255-1264

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CD150 (SLAM) Antibody, anti-mouse, REAfinity™

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