Clone:
REA151
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
SLAMF1, CDw150, SLAM, IPO3

Extended validation for CD150 (SLAM) Antibody, anti-human, REAfinity™

Specificity

Epitope competition
In order to compare the epitope specificity of an antibody, the clone being used is compared with other known clones recognizing the same antigen in a competition assay.
Other clonesOverlap in epitope recognition with REA151
A12 (7D4)++
SLAM4-
A12++
Cells were incubated with an excess of purified unconjugated CD150 (SLAM) (REA151) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.

Specifications for CD150 (SLAM) Antibody, anti-human, REAfinity™

Overview

Clone REA151 recognizes CD150, a 70 kDa cell surface glycoprotein also known as SLAM, and belongs to the Ig superfamily. It acts as a self ligand. Expression of CD150 is found on B cells, dendritic cells, and activated/memory T cells and it is involved in functions such as stimulation, proliferation, and inhibition of apoptosis of B cells, stimulation and IFN-γ production in Tʜ1 T cell clones. CD150 has been identified as the second receptor for measles virus.
Additional information: Clone REA151 displays negligible binding to Fc receptors.

Alternative names

SLAMF1, CDw150, SLAM, IPO3

Detailed product information

Technical specifications

CloneREA151
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD150 (SLAM)
Alternative names of antigenSLAMF1, CDw150, SLAM, IPO3
Molecular mass of antigen [kDa]35
Distribution of antigenB cells, dendritic cells, T cells
Entrez Gene ID6504
RRIDAB_2876993, AB_2655216, AB_2655217, AB_2655218, AB_2655219, AB_2655220, AB_2655221, AB_2876992

Resources for CD150 (SLAM) Antibody, anti-human, REAfinity™

Certificates

Please follow this
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to search for Certificates of Analysis (CoA) by lot number.

References for CD150 (SLAM) Antibody, anti-human, REAfinity™

Publications

  1. Howie, D. et al. (2002) Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation. Blood 99: 957-965
  2. Wang, N. et al. (2001) CD150 is a member of a family of genes that encode glycoproteins on the surface of hematopoietic cells. Immunogenetics 53(5): 382-394
  3. Welstead, G. G. et al. (2004) Mechanism of CD150 (SLAM) down regulation from the host cell surface by measles virus hemagglutinin protein. J. Virol. 78: 9666 -9674

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