Clone:
REA634
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
PDGF-R-beta, PDGFR-beta, PDGFR-1

Specifications for CD140b Antibody, anti-mouse, REAfinity™

Overview

Clone REA634 recognizes the mouse CD140b antigen, also known as platelet-derived growth factor receptor-β (PDGFR-β), a tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB. CD140b plays a role in the regulation of embryonic development, cell proliferation, differentiation, chemotaxis, survival, and migration. CD140b is expressed on embryonic tissues and mesenchymal-derived cells in adult mice.
Additional information: Clone REA634 displays negligible binding to Fc receptors.

Alternative names

PDGF-R-beta, PDGFR-beta, PDGFR-1

Detailed product information

Technical specifications

CloneREA634
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD140b
Alternative names of antigenPDGF-R-beta, PDGFR-beta, PDGFR-1
Molecular mass of antigen [kDa]120
Distribution of antigenother
Entrez Gene ID18596
RRIDAB_2802019, AB_2857777, AB_2655092, AB_2655093, AB_2655098, AB_2655099, AB_2655102, AB_2655103, AB_2733095

References for CD140b Antibody, anti-mouse, REAfinity™

Publications

  1. Seifert, R. A. et al. (1993) PDGF-AB requires PDGF receptor alpha-subunits for high-affinity, but not for low-affinity, binding and signal transduction. J. Biol. Chem. 268(6): 4473-4480
  2. Tallquist, M. D. et al. (2003) Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development. PLoS Biol. 1(2): E52
  3. Taneda, S. et al. (2003) Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury. J. Am. Soc. Nephrol. 14(10): 2544-2555

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