Clone:
REA911
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Pdgfr-2, PDGFR-alpha

Specifications for CD140a Antibody, anti-human, REAfinity™

Overview

Clone REA911 recognizes the human CD140a single transmembrane glycoprotein, also known as platelet derived growth factor (PDGF) receptor α. CD140 a is a tyrosine-protein kinase which functions as a cell-surface receptor for PDGFA, PDGFB, and PDGFC and is involved in the regulation of embryonic development, cell proliferation, survival, and chemotaxis. CD140a is found on platelets, fibroblasts, smooth muscle cells, glial cells, and chondrocytes as well as in brain, heart, embryo, colon tumors, and in normal colon tissues.
Additional information: Clone REA911 displays negligible binding to Fc receptors.

Alternative names

Pdgfr-2, PDGFR-alpha

Detailed product information

Technical specifications

CloneREA911
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD140a
Alternative names of antigenPdgfr-2, PDGFR-alpha
Molecular mass of antigen [kDa]120
Distribution of antigenchondrocytes, fibroblasts, platelets, other, brain, colon, heart, smooth muscle
Entrez Gene ID5156
RRIDAB_2726950, AB_2727008, AB_2726951, AB_2727009, AB_2726952, AB_2727010, AB_2726953, AB_2727011, AB_2726954, AB_2727012, AB_2726955, AB_2727006, AB_2726949, AB_2727007

Resources for CD140a Antibody, anti-human, REAfinity™

References for CD140a Antibody, anti-human, REAfinity™

Publications

  1. Matsui, T. et al. (1989) Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways. Proc. Natl. Acad. Sci. U.S.A. 86(21): 8314-8318
  2. Kawagishi, J. et al. (1995) Structure, organization, and transcription units of the human alpha-platelet-derived growth factor receptor gene, PDGFRA. Genomics 30(2): 224-232
  3. Craven, R. J. et al. (1995) Receptor tyrosine kinases expressed in metastatic colon cancer. Int. J. Cancer 60(6): 791-797

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