Clone:
REA934
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
LPS receptor

Specifications for CD14 Antibody, anti-mouse, REAfinity™

Overview

Clone REA934 recognizes the mouse CD14 antigen, a cell surface glycoprotein preferentially expressed on monocytes/macrophages, but also on granulocytes, dendritic cells, Kupffer cells, and hepatocytes. In association with toll-like receptors TLR 4 and MD-2, CD14 is a highly specific co-receptor for bacterial lipopolysaccharide (LPS) and for a variety of other pathogen-associated molecular patterns of microbial sources. The association of CD14 with LPS is mediated by the LPS-binding protein (LBP).
Additional information: Clone REA934 displays negligible binding to Fc receptors.

Alternative names

LPS receptor

Detailed product information

Technical specifications

CloneREA934
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD14
Alternative names of antigenLPS receptor
Molecular mass of antigen [kDa]35
Distribution of antigenmacrophages, monocytes, dendritic cells, granulocytes
Entrez Gene ID12475
RRIDAB_2727043, AB_2727084, AB_2727044, AB_2727085, AB_2727045, AB_2727088, AB_2727047, AB_2727086, AB_2727046, AB_2727087, AB_2727082, AB_2727042, AB_2727083

References for CD14 Antibody, anti-mouse, REAfinity™

Publications

  1. Ferrero, E. et al. (1990) CD14 is a member of the family of leucine-rich proteins and is encoded by a gene syntenic with multiple receptor genes. J. Immunol. 145(1): 331-336
  2. Gangloff, S. C. et al. (2005) Influence of CD14 on ligand interactions between lipopolysaccharide and its receptor complex. J. Immunol. 175(6): 3940-3945
  3. Drage, M. G. et al. (2009)
    TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of
    Mycobacterium tuberculosis
    .
    Cell. Immunol. 258(1): 29-37

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