Clone:
REA962
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
4-1BB ligand, 4-1BBL, TNFSF9

Specifications for CD137L (4-1BBL) Antibody, anti-mouse, REAfinity™

Overview

Clone REA962 recognizes the mouse CD137L antigen, a single-pass type II membrane protein also known as 4-1BB ligand (4-1BBL) or tumor necrosis factor ligand superfamily member 9 (Tnfsf9). CD137L is expressed on activated antigen-presenting cells and plays an essential role in regulating adaptive immune responses. Its receptor, 4-1BB is an inducible co-stimulatory member of the tumor necrosis factor receptor family expressed on activated CD4 and CD8 T cells. 4-1BB can enhance both the proliferation and the survival of murine CD4 and CD8 T cells. Recent evidence in mouse models suggests that 4-1BB/CD137L interaction plays an important role in the memory CD8 T cell response to viruses.
Additional information: Clone REA962 displays negligible binding to Fc receptors.

Alternative names

4-1BB ligand, 4-1BBL, TNFSF9

Detailed product information

Technical specifications

CloneREA962
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD137L (4-1BBL)
Alternative names of antigen4-1BB ligand, 4-1BBL, TNFSF9
Molecular mass of antigen [kDa]34
Distribution of antigenantigen-presenting cells, B cells, macrophages, fibroblasts, dendritic cells, lymphocytes, T cells, monocytes
Entrez Gene ID21950
RRIDAB_2727337, AB_2727303, AB_2727338, AB_2727304, AB_2727341, AB_2727307, AB_2727339, AB_2727305, AB_2727340, AB_2727306, AB_2727335, AB_2727302, AB_2727336

References for CD137L (4-1BBL) Antibody, anti-mouse, REAfinity™

Publications

  1. Goodwin, R. G. et al. (1993) Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur. J. Immunol. 23(10): 2631-2641
  2. Wang, C. et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol. Rev. 229(1): 192-215
  3. Ma, J. et al. (2013) The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation. Sci Signal 6(295): ra87

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