Clone:
REA786
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
FLT3, FLK-2, STK-1

Specifications for CD135 (FLT3) Antibody, anti-human, REAfinity™

Overview

Clone REA786 recognizes the human CD135 antigen, a single-pass type I membrane protein also known as Fms-like tyrosine kinase receptor 3 (FLT3) or fetal liver kinase-2 (FLK-2). CD135 belongs to the same family as FMS, KIT, and the two genes encoding PDGFRα and β. CD135 is normally expressed by hematopoietic stem and progenitor cells and expression is lost as hematopoietic cells differentiate. Although, CD135 expression is usually lost upon hematopoietic stem cell (HSC) differentiation, dendritic cells are an exception, as mature dendritic cells (DCs) display persistent FLT3 expression. CD135 is also expressed on malignant hematopoietic cells including AML, ALL, and CML-BC. All hematopoietic cells develop from CD135 negative hematopoietic stem cells through CD135 positive progenitor cells. In synergy with other growth factors like G-CSF, GM-CSF, SCF, and IL-3, ligation of CD135 with FLT3 ligand promotes the differentiation, proliferation, and survival of hematopoietic progenitor cells and of dendritic cells. As a result early B cell lineage differentiation as well as expansion of monocytes and immature dendritic cells are stimulated.
Additional information: Clone REA786 displays negligible binding to Fc receptors.

Alternative names

FLT3, FLK-2, STK-1

Detailed product information

Technical specifications

CloneREA786
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD135 (FLT3)
Alternative names of antigenFLT3, FLK-2, STK-1
Molecular mass of antigen [kDa]110
Distribution of antigendendritic cells, hematopoietic stem and progenitor cells
Entrez Gene ID2322
RRIDAB_2654960, AB_2654961, AB_2654962, AB_2654963, AB_2654964, AB_2654965, AB_2654966, AB_2654967, AB_2654968, AB_2654959

References for CD135 (FLT3) Antibody, anti-human, REAfinity™

Publications

  1. Small, D. et al. (1994)
    STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34
    +
    human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.
    Proc. Natl. Acad. Sci. U.S.A. 91(2): 459-463
  2. Rosnet, O. et al. (1996) Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells. Leukemia 10(2): 238-248
  3. Leung, A. Y. et al. (2013) FLT3 inhibition: a moving and evolving target in acute myeloid leukaemia. Leukemia 27(2): 260-268

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