Clone:
REA540
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
TNFRSF4, OX-40, Txgp1, MRC OX40

Specifications for CD134 (OX40) Antibody, anti-rat, REAfinity™

Overview

Clone REA540 recognizes the rat CD134 (OX40) antigen, a 50 kDa glycoprotein which is a member of the TNFR superfamily. It contains a typical signal sequence and a single putative transmembrane sequence of 25 predominantly hydrophobic amino acids giving an extracellular domain of 191 amino acids and a cytoplasmic domain of 36 amino acids. The expression of CD134 is restricted to activated rat CD4
+
T cells and is up-regulated within hours after activation. CD134 and its ligand CD252 (CD134L, OX40L), which is expressed on activated T and B lymphocytes and also a member of the tumor necrosis factor receptor superfamily, were suggested to mediate the interaction between T cells and B cells.
Additional information: Clone REA540 displays negligible binding to Fc receptors.

Alternative names

TNFRSF4, OX-40, Txgp1, MRC OX40

Detailed product information

Technical specifications

CloneREA540
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesrat
AntigenCD134 (OX40)
Alternative names of antigenTNFRSF4, OX-40, Txgp1, MRC OX40
Molecular mass of antigen [kDa]28
Distribution of antigenT cells
Entrez Gene ID25572
RRIDAB_2654922, AB_2654923, AB_2654924, AB_2654925, AB_2654926, AB_2654927, AB_2654928, AB_2654921

References for CD134 (OX40) Antibody, anti-rat, REAfinity™

Publications

  1. Calderhead, D. M. et al. (1993) Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions. J. Immunol. 151: 5261-5271
  2. Mallett, S. et al. (1990) Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor. EMBO J. 9(4): 1063-1068
  3. Al-Shamkhanie, A. et al. (1997) Affinity and kinetics of the interaction between soluble trimeric OX40 ligand, a member of the tumor necrosis factor superfamily, and its receptor OX40 on activated T cells. J. Biol. Chem. 272: 5275-5282

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