Clone:
REA403
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
IL2RG, IL-2RG, p64, IL-2Rγ

Specifications for CD132 Antibody, anti-mouse, REAfinity™

Overview

Clone REA403 recognizes the mouse CD132 antigen, a 65-70 kDa single-pass type I membrane protein also known as common γ chain, which is shared by the IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21 receptors. CD132 is expressed on T and B lymphocytes, NK cells, monocytes, and granulocytes. It is involved in intracellular signal transduction by associating with effector molecules within the cytoplasm. The most common form of severe combined immune deficiency in humans, with lack of circulating T cells, a normal or increased number of B lymphocytes, and an X-linked pattern of inheritance (XSCID) has been shown to be due to defects of the CD132 gene.
Additional information: Clone REA403 displays negligible binding to Fc receptors.

Alternative names

IL2RG, IL-2RG, p64, IL-2Rγ

Detailed product information

Technical specifications

CloneREA403
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD132
Alternative names of antigenIL2RG, IL-2RG, p64, IL-2Rγ
Molecular mass of antigen [kDa]40
Distribution of antigenmonocytes, lymphocytes, NK cells, granulocytes
Entrez Gene ID16186
RRIDAB_2654880, AB_2654881, AB_2654882, AB_2654883, AB_2654884, AB_2654879

References for CD132 Antibody, anti-mouse, REAfinity™

Publications

  1. Andersson, A. et al. (1997) Mouse macrophage development in the absence of the common gamma chain: defining receptor complexes responsible for IL-4 and IL-13 signaling. Eur. J. Immunol. 27(7): 1762-1768
  2. DiSanto, J. P. et al. (1994) The murine interleukin-2 receptor gamma chain gene: organization, chromosomal localization and expression in the adult thymus. Eur. J. Immunol. 24(12): 3014-3018
  3. Kumaki, S. et al. (1993) Cloning of the mouse interleukin 2 receptor gamma chain: demonstration of functional differences between the mouse and human receptors. Biochem. Biophys. Res. Commun. 193(1): 356-363

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