Clone:
REA249
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CSF2RB, CDw131, IL3RB, IL5RB, SMDP5

Specifications for CD131 Antibody, anti-human, REAfinity™

Overview

Clone REA249 recognizes the human CD131 antigen, a type I transmembrane glycoprotein also known as IL-3R common subunit β or GM-CSF/IL-3/IL-5 receptor common β chain. CD131 forms heterodimers with the α subunit of the receptor complexes for human granulocyte-macrophage colony stimulating factor (GM-CSFR), interleukin 3 (IL-3R), and interleukin 5 (IL-5R). These cytokine receptors are expressed by several different cell types like neutrophils, eosinophils, monocytes, endothelial cells, fibroblasts, and hematopoietic progenitor cells.
Additional information: Clone REA249 displays negligible binding to Fc receptors.

Alternative names

CSF2RB, CDw131, IL3RB, IL5RB, SMDP5

Detailed product information

Technical specifications

CloneREA249
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD131
Alternative names of antigenCSF2RB, CDw131, IL3RB, IL5RB, SMDP5
Molecular mass of antigen [kDa]96
Distribution of antigenendothelial cells, fibroblasts, eosinophils, neutrophils, hematopoietic stem and progenitor cells
Entrez Gene ID1439
RRIDAB_2654869, AB_2654870

References for CD131 Antibody, anti-human, REAfinity™

Publications

  1. Rossjohn, J. et al. (2000) Structure of the activation domain of the GM-CSF/IL-3/IL-5 receptor common beta-chain bound to an antagonist. Blood 95(8): 2491-2498
  2. Hansen, G. et al. (2008) The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. Cell 134(3): 496-507

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CD131 Antibody, anti-human, REAfinity™

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