Clone:
D7715A7
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
rat IgG2bκ
Applications:
FA, FC
Alternative names:
IL6RA, IL-6R, IL-6R-alpha, IL-6RA, IL-6R 1

Specifications for CD126 (IL-6Rα) Antibody, anti-mouse

Overview

Clone D7715A7 recognizes the mouse CD126 antigen, a type I cytokine receptor also known as interleukin 6 receptor subunit alpha (IL-6Rα) or membrane glycoprotein 80 (gp80). CD126 is expressed on activated T and B cells, monocytes, hepatocytes, and plasma cells. It associates with the IL-6 receptor β chain (CD130 or gp130) resulting in the formation of a functional high affinity IL-6 receptor complex. IL-6 plays essential roles in immune response, acute phase reaction, and hematopoiesis. It is an essential factor for B cell differentiation to antibody-forming cells. Deregulated expression of the IL-6 gene is involved in polyclonal plasma cell abnormalities and oncogenesis of plasma cell neoplasias. IL-6 functions as a potent growth factor for multiple myelomas, as well as plasmacytomas. Clone D7715A7 blocks IL-6/IL-6 receptor interactions.

Alternative names

IL6RA, IL-6R, IL-6R-alpha, IL-6RA, IL-6R 1

Detailed product information

Technical specifications

CloneD7715A7
Clonalitymonoclonal
Isotyperat IgG2bκ
Isotype controlIsotype Control Antibody, rat IgG2b
Hostrat
Type of antibodyPrimary antibodies, Functional-grade antibodies
Speciesmouse
AntigenCD126 (IL-6Rα)
Alternative names of antigenIL6RA, IL-6R, IL-6R-alpha, IL-6RA, IL-6R 1
Molecular mass of antigen [kDa]49
Distribution of antigenB cells, T cells, monocytes, plasma cells
Entrez Gene ID16194
RRIDAB_2654823, AB_2654824, AB_2654825, AB_2654826, AB_2654827, AB_2654828, AB_2654804

References for CD126 (IL-6Rα) Antibody, anti-mouse

Publications

  1. Yadav, M. et al. (2008) Cutting edge: vasoactive intestinal peptide (VIP) induces differentiation of Th17 cells with a distinctive cytokine Profile. J. Immunol. 180(5): 2772-2776
  2. Walker, F. et al. (2008) IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice. Blood 111(8): 3978-3985
  3. Sugita, T. et al. (1990) Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis. J. Exp. Med. 171(6): 2001-2009

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