Clone:
REA114
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
IL3RA, CDw123, SUT-1

Specifications for CD123 Antibody, anti-mouse, REAfinity™

Overview

Clone REA114 recognizes CD123, the alpha chain of the IL-3 receptor. CD123 is 60–70 kDa membrane glycoprotein and interacts in mice with common beta chain (betac) and beta IL-3 subunits to form functional heterodimeric IL-3 receptors. CD123 alone can bind IL-3 with low affinity, however a high affinity binding is displayed by the heterodimeric forms. Besides ligand binding, the alpha chain of IL-3R was also shown to be necessary for the activation of STAT-5. Expression of CD123 is widely found in hematopoietic cells and in addition on basophils, mast cells, and megakaryocytes. AKR, RF, A/J, and NZB mouse strains carry a 5-bp deletion in the IL-3Ra gene and thus lack the expression of CD123.
Additional information: Clone REA114 displays negligible binding to Fc receptors.

Alternative names

IL3RA, CDw123, SUT-1

Detailed product information

Technical specifications

CloneREA114
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD123
Alternative names of antigenIL3RA, CDw123, SUT-1
Molecular mass of antigen [kDa]42
Distribution of antigenB cells, granulocytes, monocytes, macrophages, endothelial cells, mast cells, megakaryocytes, red blood cells, eosinophils, basophils, bone marrow, brain, placenta
Entrez Gene ID16188
RRIDAB_2654775, AB_2654776, AB_2654777, AB_2654778, AB_2654779, AB_2654780, AB_2654781, AB_2654774

References for CD123 Antibody, anti-mouse, REAfinity™

Publications

  1. Hara, T. et al. (1995) Interleukin-3 (IL-3) poor-responsive inbred mouse strains carry the identical deletion of a branch point in the IL-3 receptor alpha subunit gene. Blood 85: 2331-2336
  2. Reddy, E. P. et al. (2000) IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled. Oncogene 19(21): 2532-2547
  3. Lehmann, C. et al. (2014) Longitudinal analysis of distribution and function of plasmacytoid dendritic cells in peripheral blood and gut mucosa of HIV infected patients. J. Infect. Dis. 209: 940-949

Related products for
CD123 Antibody, anti-mouse, REAfinity™

2 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?