Clone:
REA167
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MC, FC
Alternative names:
IL2RB, IL-15RB, P70-75

Specifications for CD122 (IL-2Rβ) Antibody, anti-human, REAfinity™

Overview

Clone REA167 recognizes CD122, the 75 KDa β subunit of the high and intermediate affinity interleukin 2 receptor (IL-2R). CD122 is a type I transmembrane protein, and together with α subunit (CD25) or with α and γ (CD132) subunit, it forms the heteromeric intermediate and high affinity IL-2 receptors, respectively. In addition, CD122 is also a component of the IL-15 receptor complex. Expression of CD122 is found constitutively in CD8 cytotoxic T cells but not in CD4 Tʜ cells and is further induced upon T cell activation. CD16
+
NK lymphocytes also express CD122 constitutively. CD122 is essential for IL-2 signaling.
Additional information: Clone REA167 displays negligible binding to Fc receptors.      

Alternative names

IL2RB, IL-15RB, P70-75

Detailed product information

Technical specifications

CloneREA167
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD122 (IL-2Rβ)
Alternative names of antigenIL2RB, IL-15RB, P70-75
Molecular mass of antigen [kDa]58
Distribution of antigenT cells, NK cells
Entrez Gene ID3560
RRIDAB_2654756, AB_2654757, AB_2654758, AB_2654759, AB_2654760, AB_2654761, AB_2654762, AB_2654763, AB_2654764, AB_2654765, AB_2819664

References for CD122 (IL-2Rβ) Antibody, anti-human, REAfinity™

Publications

  1. Gesbert, F. et al. (2005) IL-2 responsiveness of CD4 and CD8 lymphocytes: further investigations with human IL-2Rß transgenic mice. Int. Immunol. 17: 1093-1102
  2. Friedmann, M. C. et al. (1996) Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation. Proc. Natl. Acad. Sci. U.S.A. 93(5): 2077-2082
  3. Migone, T. S. et al. (1998) Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation. Mol. Cell. Biol. 18(11): 6416-6422

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