Clone:
REA744
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MC
Alternative names:
IL-1R-2, IL-1R-II, IL-1RII, IL-1R-beta, IL-1Rb

Specifications for CD121b (IL-1R2) Antibody, anti-human, REAfinity™

Overview

Clone REA744 recognizes the human CD121b antigen, also known as interleukin-1 receptor type II (IL-1R2). CD121b is a 60 kDa cytokine receptor, which is a ligand for interleukin-1 (IL-1). There are two forms of the IL-1 receptors. The type I receptor is mainly involved in transmitting the inflammatory effects of IL-1 while type II receptor plays a role as a suppressor of IL-1 activity by competing for IL-1 binding.
Additional information: Clone REA744 displays negligible binding to Fc receptors.

Alternative names

IL-1R-2, IL-1R-II, IL-1RII, IL-1R-beta, IL-1Rb

Detailed product information

Technical specifications

CloneREA744
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD121b (IL-1R2)
Alternative names of antigenIL-1R-2, IL-1R-II, IL-1RII, IL-1R-beta, IL-1Rb
Molecular mass of antigen [kDa]44
Distribution of antigenT cells
Entrez Gene ID7850
RRIDAB_2654747, AB_2654748, AB_2654749, AB_2654750, AB_2654751, AB_2654752, AB_2654753, AB_2654754, AB_2654755

References for CD121b (IL-1R2) Antibody, anti-human, REAfinity™

Publications

  1. McMahan, C. J. et al. (1991) A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J. 10(10): 2821-2832
  2. Kuno, K. et al. (1994) The IL-1 receptor signaling pathway. J. Leukoc. Biol. 56(5): 542-547
  3. Liu, C. et al. (1996) Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. J. Biol. Chem. 271(34): 20965-20972

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