Clone:
REA880
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
LFA-1

Specifications for CD11a/CD18 Antibody, anti-mouse, REAfinity™

Overview

Clone REA 880 recognizes the CD11a/CD18 heterodimer, also known as lymphocyte function–associated antigen 1 (LFA-1). LFA-1 is a member of the integrin family and consists of two chains, a (CD11a) and b2 (CD18). It is expressed on T and B cells as well as on macrophages and neutrophils. LFA-1 plays an essential role in the immune system, e.g., in leukocyte adhesion by interaction with ICAM-1 and ICAM-2, in cytotoxic T cell–mediated killing, antibody-dependent killing by granulocytes and monocytes, and in T cell proliferation.
Additional information: Clone REA880 displays negligible binding to Fc receptors.

Alternative names

LFA-1

Detailed product information

Technical specifications

CloneREA880
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD11a/CD18
Alternative names of antigenLFA-1
Molecular mass of antigen [kDa]209
Distribution of antigenT cells, B cells, macrophages
Entrez Gene ID16408, 16414
RRIDAB_2726625, AB_2726555, AB_2726626, AB_2726556, AB_2726627, AB_2726623, AB_2726554, AB_2726624

References for CD11a/CD18 Antibody, anti-mouse, REAfinity™

Publications

  1. Kaufmann, Y. et al. (1991) Cloning of the murine lymphocyte function-associated molecule-1 alpha-subunit and its expression in COS cells. J. Immunol. 147(1): 369-374
  2. Lub, M. et al. (1995) Ins and outs of LFA-1. Immunol. Today 16(10): 479-483
  3. Liu, Z. et al. (2006) Differential roles for beta2 integrins in experimental autoimmune bullous pemphigoid. Blood 107(3): 1063-1069
  4. Liu, Y. et al. (2011) Expression of p16INK4a prevents cancer and promotes aging in lymphocytes. Blood 117: 3257-3267

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CD11a/CD18 Antibody, anti-mouse, REAfinity™

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