Clone:
REA787
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
c-kit, PBT, SCFR, KIT

Specifications for CD117 Antibody, anti-human, REAfinity™

Overview

Clone REA787 recognizes the human CD117 antigen, also known as c-kit or SCF receptor, which is a 145 kDa receptor tyrosine kinase that is involved in stem cell signaling, activation, and proliferation. The CD117 antigen is expressed on about 1–3% of mononuclear cells from peripheral blood mononuclear cells (PBMCs) or cord blood and on up to 10% of bone marrow cells. CD117 is further expressed on basophils, myeloid dendritic cells, TCRα/β
+
T cells, CD19
+
B cells, and CD56
+
NK cells, as well as on mast cells, melanocytes, and acute myeloid leukemia (AML) blasts. Clone REA787 recognizes a different epitope than clone AC126 and may interfere with SCF-binding. It is therefore not recommended for indirect cell isolation, but is optimal for flow cytometric analysis of cells separated with the CD117 MicroBead Kit, human.
Additional information: Clone REA787 displays negligible binding to Fc receptors.

Alternative names

c-kit, PBT, SCFR, KIT

Detailed product information

Technical specifications

CloneREA787
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD117
Alternative names of antigenc-kit, PBT, SCFR, KIT
Molecular mass of antigen [kDa]107
Distribution of antigenB cells, macrophages, fibroblasts, mast cells, megakaryocytes, myeloid leukemia cells, T cells, red blood cells, NK cells, cancer stem cells, hematopoietic stem and progenitor cells, leukemia cells, bone marrow, brain, kidney, liver, lung
Entrez Gene ID3815
RRIDAB_2654577, AB_2654578, AB_2654579, AB_2654580, AB_2654581, AB_2654582, AB_2654583, AB_2654584, AB_2654585, AB_2654586, AB_2654587, AB_2654588, AB_2654589, AB_2654576

References for CD117 Antibody, anti-human, REAfinity™

Publications

  1. Bühring, H. J. et al. (1991) The product of the proto-oncogene c-kit (P145c-kit) is a human bone marrow surface antigen of hematopoietic precursor cells which is expressed on a subset of acute non-lymphoblastic cells. Leukemia 5: 854-860
  2. Kubo, H. et al. (2008) Increased cardiac myocyte progenitors in failing human hearts. Circulation 118: 649-657
  3. Berglund, E. et al. (2013)
    Evidence for Ca
    2+
    -regulated ATP release in gastrointestinal stromal tumors.
    Exp. Cell Res. 319(8): 1229-1238

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