Clone:
REAL565
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
LAMP-1, LAMPA, LGP120, LAMP1

Specifications for CD107a (LAMP-1) Antibody, anti-human, REAdye_lease™

Overview

Clone REAL565 is an antibody fragment derived from the full CD107a antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL565 recognizes the CD107a antigen, also known as lysosome-associated membrane protein 1 (LAMP-1), a 110–140 kDa type I membrane glycoprotein. It is a widely expressed intracellular protein, located in the lysosomal/endosomal membrane. CD107a transiently located on the plasma membrane can be used as a marker for CD8+ T cell degranulation following stimulation. It is also expressed to a lower extent on activated NK cells.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

LAMP-1, LAMPA, LGP120, LAMP1

Detailed product information

Technical specifications

CloneREAL565
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD107a (LAMP-1)
Alternative names of antigenLAMP-1, LAMPA, LGP120, LAMP1
Distribution of antigendendritic cells, endothelial cells, epithelial cells, granulocytes, macrophages, platelets, T cells, neutrophils, tonsil, spleen
RRIDAB_2857700, AB_2857701

References for CD107a (LAMP-1) Antibody, anti-human, REAdye_lease™

Publications

  1. Mane, S. M. et al. (1989) Purification and characterization of human lysosomal membrane glycoproteins. Arch Biochem Biophys. 268(1): 360-378
  2. Betts, M. R. et al. (2003)
    Sensitive and viable identification of antigen-specific CD8
    +
    T cells by a flow cytometric assay for degranulation.
    J. Immunol. Methods 281: 65-78
  3. Wang, Q. et al. (2017) LAMP1 expression is associated with poor prognosis in breast cancer. Oncol Lett 14(4): 4729-4735

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