Clone:
REA1078
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
VCAM1, VCAM1B

Specifications for CD106 (VCAM-1) Antibody, anti-rat, REAfinity™

Overview

Clone REA1078 recognizes the CD106 antigen, a 110 kDa transmembrane protein also known as vascular cell adhesion protein 1 (VCAM-1). CD106 is expressed on bone marrow stromal cells, myeloid cells, and dendritic cells, but not on peripheral leukocytes. Expression on endothelial cells is upregulated upon inflammatory cytokine stimulation. CD106 (VCAM-1) is an endothelial ligand for the very late antigen-4 (VLA-4 or α4β1) of the β1 subfamily of integrins, and for integrin α4β7. It mediates the adhesion of lymphocytes, monocytes, eosinophils, and basophils to vascular endothelium. CD106 also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development of atherosclerosis and rheumatoid arthritis.
Additional information: Clone REA1078 displays negligible binding to Fc receptors.

Alternative names

VCAM1, VCAM1B

Detailed product information

Technical specifications

CloneREA1078
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesrat
AntigenCD106 (VCAM-1)
Alternative names of antigenVCAM1, VCAM1B
Molecular mass of antigen [kDa]79
Distribution of antigendendritic cells, endothelial cells, macrophages, stromal cells
Entrez Gene ID25361
RRIDAB_2733593, AB_2733720, AB_2733721, AB_2733301, AB_2733302, AB_2732931, AB_2732932, AB_2733980, AB_2733981, AB_2733470, AB_2733471, AB_2733592

References for CD106 (VCAM-1) Antibody, anti-rat, REAfinity™

Publications

  1. Hession, C. et al. (1992) Cloning of murine and rat vascular cell adhesion molecule-1. Biochem. Biophys. Res. Commun. 183(1): 163-169
  2. Barreiro, O. et al. (2002) Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes. J. Cell Biol. 157(7): 1233-1245
  3. Gao, Z. et al. (2012) Vascular endothelial growth factor participates in modulating the C6 glioma-induced migration of rat bone marrow-derived mesenchymal stem cells and upregulates their vascular cell adhesion molecule-1 expression. Exp Ther Med. 4(6): 993-998