Clone:
MR106
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
VCAM1, VCAM1B

Specifications for CD106 (VCAM-1) Antibody, anti-rat

Overview

Clone MR106 recognizes the CD106 antigen, a 110 kDa transmembrane protein also known as vascular cell adhesion protein 1 (VCAM-1). CD106 is expressed on bone marrow stromal cells, myeloid cells, and dendritic cells, but not on peripheral leukocytes. Expression on endothelial cells is upregulated upon inflammatory cytokine stimulation. CD106 is an endothelial ligand for the very late antigen-4 (VLA-4 or α4β1) of the β1 subfamily of integrins, and for integrin α4β7. It mediates the adhesion of lymphocytes, monocytes, eosinophils, and basophils to vascular endothelium. CD106 also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development of atherosclerosis and rheumatoid arthritis.

Alternative names

VCAM1, VCAM1B

Detailed product information

Technical specifications

CloneMR106
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Speciesrat
AntigenCD106 (VCAM-1)
Alternative names of antigenVCAM1, VCAM1B
Molecular mass of antigen [kDa]79
Distribution of antigenendothelial cells, macrophages, dendritic cells, myeloid cells, stromal cells
Entrez Gene ID25361
RRIDAB_2654460, AB_2654461, AB_2654462, AB_2654459

References for CD106 (VCAM-1) Antibody, anti-rat

Publications

  1. Hession, C. et al. (1992) Cloning of murine and rat vascular cell adhesion molecule-1. Biochem. Biophys. Res. Commun. 183(1): 163-169
  2. Barreiro, O. et al. (2002) Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes. J. Cell Biol. 157(7): 1233-1245
  3. Gao, Z. et al. (2012) Vascular endothelial growth factor participates in modulating the C6 glioma-induced migration of rat bone marrow-derived mesenchymal stem cells and upregulates their vascular cell adhesion molecule-1 expression. Exp Ther Med. 4(6): 993-998

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