Clone:
REA971
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
VCAM1, INCAM-100

Specifications for CD106 (VCAM-1) Antibody, anti-mouse, REAfinity™

Overview

Clone REA971 recognizes the mouse CD106 antigen, a 110 kDa single-chain type I glycoprotein, also known as vascular cell adhesion protein 1 (VCAM-1). CD106 is expressed on bone marrow cells, stromal cells, and inflamed vascular endothelium as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Upregulation of CD106 in endothelial cells by inflammatory stimuli and cytokines occurs as a result of increased gene transcription. Primarily, CD106 is an endothelial ligand for very late antigen-4 (VLA-4) or integrin α-4/β-7 and mediates both adhesion and signal transduction. The interactions play a pathophysiologic role in leukocyte adhesion, transmigration, and co-stimulation of T cell proliferation.
Additional information: Clone REA971 displays negligible binding to Fc receptors.

Alternative names

VCAM1, INCAM-100

Detailed product information

Technical specifications

CloneREA971
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD106 (VCAM-1)
Alternative names of antigenVCAM1, INCAM-100
Molecular mass of antigen [kDa]79
Distribution of antigenendothelial cells, stromal cells, bone marrow
Entrez Gene ID22329
RRIDAB_2727413, AB_2727478, AB_2727414, AB_2727479, AB_2727415, AB_2727480, AB_2727416, AB_2727476, AB_2727412, AB_2727477

References for CD106 (VCAM-1) Antibody, anti-mouse, REAfinity™

Publications

  1. Kumar, A. G. et al. (1994) Murine VCAM-1. Molecular cloning, mapping, and analysis of a truncated form J. Immunol. 153(9): 4088-4098
  2. Ou, R. et al. (2008) Regulation of immune response and inflammatory reactions against viral infection by VCAM-1. J. Virol. 82(6): 2952-2965
  3. Kokovay, E. et al. (2012) VCAM1 is essential to maintain the structure of the SVZ niche and acts as an environmental sensor to regulate SVZ lineage progression Cell Stem Cell 11(2): 220-230

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