Clone:
REA456
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
Itgb4

Specifications for CD104 (Integrin β4) Antibody, anti-mouse, REAfinity™

Overview

Clone REA456 recognizes the mouse CD104 antigen, a single-pass type I membrane protein which is also known as integrin β4 (Itgb4). Integrins are a family of heterodimeric glycoprotein receptors and exist as non-covalently bound α and β subunits. CD104 interacts with α6 integrin and serves as receptor for laminin and component of hemidesmosomes. Expression of α6β4 integrin is found in the basal aspect of stratified epithelia such as epidermis, stratified squamous epithelium of squamous mucosa, urotheliumin, and certain tumor cells. CD104 is likely to play a pivotal role in the biology of invasive carcinoma.
Additional information: Clone REA456 displays negligible binding to Fc receptors.

Alternative names

Itgb4

Detailed product information

Technical specifications

CloneREA456
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD104 (Integrin β4)
Alternative names of antigenItgb4
Molecular mass of antigen [kDa]199
Distribution of antigenepithelial cells, tumor cells
Entrez Gene ID192897
RRIDAB_2654414, AB_2654415, AB_2654416, AB_2654417, AB_2654418, AB_2654419, AB_2654420, AB_2654413

References for CD104 (Integrin β4) Antibody, anti-mouse, REAfinity™

Publications

  1. Murgia, C. et al. (1998) Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain. EMBO J. 17(14): 3940-3951
  2. Pal-Ghosh, S. et al. (2011) MMP9 cleavage of the β4 integrin ectodomain leads to recurrent epithelial erosions in mice. J. Cell. Sci. 124(Pt 15): 2666-2675
  3. Simon-Assmann, P. et al. (1994) Differential expression of laminin isoforms and alpha 6-beta 4 integrin subunits in the developing human and mouse intestine. Dev. Dyn. 201(1): 71-85

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