Clone:
REA301
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
EWI-101, Gm1016, Gm734, IGSF2

Specifications for CD101 Antibody, anti-mouse, REAfinity™

Overview

Clone REA301 recognizes the mouse CD101 antigen, a type I transmembrane glycoprotein also known as immunoglobulin superfamily member 2 (IgSF2) or V7. CD101 is expressed on monocytes, granulocytes, dendritic cells (DCs), and activated T cells. In humans CD101 inhibits the proliferative response of T cells to allogeneic cells or immobilized anti-CD3 antibody, suggesting that engagement of CD101 can antagonize TCR/CD3-mediated lymphocyte activation. Moreover, human peripheral CD8
+
T cells that express CD101 and CD103 display suppressive function after activation with intraepithelial cells or placental trophoblasts. In addition to its role on T cells, triggering CD101 on human cutaneous DCs inhibits T cell proliferation via interleukin 10 (IL-10) production, suggesting that the CD101 molecule may be involved in tolerance induction. Studies in mice showed that cell surface expression of CD101 is highly correlated with functional suppressor activity within CD4
+
CD25
+
T regulatory cells both
in vitro
and
in vivo
.
Additional information: Clone REA301 displays negligible binding to Fc receptors.

Alternative names

EWI-101, Gm1016, Gm734, IGSF2

Detailed product information

Technical specifications

CloneREA301
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD101
Alternative names of antigenEWI-101, Gm1016, Gm734, IGSF2
Molecular mass of antigen [kDa]112
Distribution of antigengranulocytes, monocytes, dendritic cells, T cells
Entrez Gene ID630146
RRIDAB_2654345, AB_2654346, AB_2654347, AB_2654348, AB_2752032

References for CD101 Antibody, anti-mouse, REAfinity™

Publications

  1. Fernandez, I. et al. (2007)
    CD101 surface expression discriminates potency among murine FoxP3
    +
    regulatory T cells.
    J. Immunol. 179(5): 2808-2814
  2. Mohammed, J. P. et al. (2011)
    Identification of CD101 as a susceptibility gene for
    Novosphingobium aromaticivorans
    -induced liver autoimmunity.
    J. Immunol. 187(1): 337-349
  3. Penha-Gonçalves, C. et al. (2003) Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice. Diabetes 52(6): 1551-1556

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