Clone:
REA877
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC, MC
Alternative names:
MME, CALLA, NEP, SFE, gp100, Neprilysin, Enkephalinase

Specifications for CD10 Antibody, anti-human, REAfinity™

Overview

Clone REA877 recognizes the human CD10 antigen, also known as the common acute lymphoblastic leukemia antigen (CALLA). CD10 is a 100 kDa cell surface molecule identical to human membrane-associated neutral endopeptidase (NEP) and also known as neprilysin or enkephalinase.
Human CD10 is expressed on a wide variety of normal and neoplastic cell types from different tissues including neural and hematopoietic cells. It is expressed on pre– and pro–B cells and is involved in B cell development and differentiation. The antigen is also present on mature neutrophils, T cell precursors, and some T cell leukemias/lymphomas. Furthermore, CD10 is expressed on neoplastic cells of several B lymphoid leukemias/lymphomas.
Additional information: Clone REA877 displays negligible binding to Fc receptors.

Alternative names

MME, CALLA, NEP, SFE, gp100, Neprilysin, Enkephalinase

Detailed product information

Technical specifications

CloneREA877
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD10
Alternative names of antigenMME, CALLA, NEP, SFE, gp100, Neprilysin, Enkephalinase
Molecular mass of antigen [kDa]85
Distribution of antigenB cells, epithelial cells, fibroblasts, granulocytes, stromal cells, T cells, bone marrow, brain, gut, kidney, smooth muscle
Entrez Gene ID4311
RRIDAB_2726671, AB_2726756, AB_2726672, AB_2726757, AB_2726673, AB_2726761, AB_2726677, AB_2726762, AB_2726678, AB_2726758, AB_2726674, AB_2726759, AB_2726675, AB_2726760, AB_2726676, AB_2726754, AB_2726670, AB_2726755

References for CD10 Antibody, anti-human, REAfinity™

Publications

  1. Shipp, M. A. and Look, A. T. (1993) Hematopoietic differentiation antigens that are membrane-associated enzymes: cutting is the key! Blood 82: 1052-1070
  2. Kalled, S. L. et al. (1995) The distribution of CD10 (NEP 24.11, CALLA) in human and mice is similar in non-lymphoid organs but differ within the hematopoietic system: absence on murine T and B lymphoid progenitors. Eur. J. Immunol. 25: 677-687

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