Clone:
REA355
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
LD78alpha, MIP1-alpha, MIP1A, Scya3, L2G25B, SIS-α, Small-inducible cytokine A3, TY-5

Specifications for CCL3 (MIP-1α) Antibody, anti-mouse, REAfinity™

Overview

Clone REA355 recognizes the mouse C-C motif chemokine 3 (CCL3) antigen also known as Macrophage inflammatory protein 1 α (MIP-1a). CCL3 is a cytokine belonging to the members of the β (CC) subfamily of chemokines. It is produced by T cells, B cells, Langerhans cells, neutrophils and macrophages. CCL3 is involved in activation and recruitment of lymphocytes, monocytes, and granulocytes during acute inflammation and plays a role as a chemoattractant of monocytes, B cells, eosinophils and cytotoxic T cells. It has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. The functional receptor for CCL3 has been identified as CCR1 and CCR5. CCL3 deficient mice showed increased resistance to viral-induced mortality following infection with HSV-1.
Additional information: Clone REA355 displays negligible binding to Fc receptors.

Alternative names

LD78alpha, MIP1-alpha, MIP1A, Scya3, L2G25B, SIS-α, Small-inducible cytokine A3, TY-5

Detailed product information

Technical specifications

CloneREA355
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCCL3 (MIP-1α)
Alternative names of antigenLD78alpha, MIP1-alpha, MIP1A, Scya3, L2G25B, SIS-α, Small-inducible cytokine A3, TY-5
Molecular mass of antigen [kDa]8
Distribution of antigenB cells, T cells, Langerhans cells, macrophages, neutrophils
Entrez Gene ID20302
RRIDAB_2651381, AB_2651382, AB_2651383, AB_2651384

References for CCL3 (MIP-1α) Antibody, anti-mouse, REAfinity™

Publications

  1. Bernardini, G. et al. (2008) CCL3 and CXCL12 regulate trafficking of mouse bone marrow NK cell subsets. Blood 111(7): 3626-3634
  2. Fujita, H. et al. (2004) Expression and regulation of RANTES/CCL5, MIP-1alpha/CCL3, and MIP-1beta/CCL4 in mouse Langerhans cells. J. Invest. Dermatol. 122(5): 1331-1333
  3. Grove, M. et al. (1990) Sequence of the murine haemopoietic stem cell inhibitor/macrophage inflammatory protein 1 alpha gene. Nucleic Acids Res. 18(18): 5561

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