Clone:
REA257
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
G0S19-1, LD78alpha, MIP-1-alpha, MIP1A, Scya3, tonsillar lymphocyte LD78 alpha protein

Specifications for CCL3 (MIP-1α) Antibody, anti-human, REAfinity™

Overview

Clone REA257 recognizes the C-C motif chemokine 3 (CCL3) antigen also known as macrophage inflammatory protein 1 alpha (MIP-1α). CCL3 is a cytokine belonging to the members of the β (CC) subfamily of chemokines. It is produced by T cells, B cells, Langerhans cells, neutrophils, and macrophages. CCL3 is involved in activation and recruitment of lymphocytes, monocytes, and granulocytes during acute inflammation and plays a role as a chemoattractant of monocytes, B cells, eosinophils, and cytotoxic T cells. It has been identified as a stem cell inhibitory factor that can inhibit the proliferation of hematopoietic stem cells
in vitro
as well as
in vivo
. Moreover, CCL3 has been reported to be involved in susceptibility of HIV infection and disease progression of AIDS. The functional receptor for CCL3 has been identified as CCR1 and CCR5.
Additional information: Clone REA257 displays negligible binding to Fc receptors.

Alternative names

G0S19-1, LD78alpha, MIP-1-alpha, MIP1A, Scya3, tonsillar lymphocyte LD78 alpha protein

Detailed product information

Technical specifications

CloneREA257
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCCL3 (MIP-1α)
Alternative names of antigenG0S19-1, LD78alpha, MIP-1-alpha, MIP1A, Scya3, tonsillar lymphocyte LD78 alpha protein
Molecular mass of antigen [kDa]8
Distribution of antigenB cells, T cells, dendritic cells, macrophages
Entrez Gene ID6348
RRIDAB_2651372, AB_2651373, AB_2651374, AB_2651375, AB_2651376, AB_2651377, AB_2651378, AB_2651379, AB_2651380, AB_2651371

References for CCL3 (MIP-1α) Antibody, anti-human, REAfinity™

Publications

  1. Li, L. et al. (2005) Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. Cell Res. 15(11-12): 923-934
  2. Wolpe, S. D. and Cerami, A. (1989) Macrophage inflammatory proteins 1 and 2: members of a novel superfamily of cytokines. FASEB J. 3: 2565-2573
  3. Menten, P. et al. (2002) Macrophage inflammatory protein-1. Cytokine Growth Factor Rev. 13(6): 455-481

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