Clone:
REAL1385
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
CPA1, CPA

Specifications for Carboxypeptidase A1 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL1385 is an antibody fragment derived from the full Carboxypeptidase A1 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1385 recognizes the zinc metalloprotease Carboxypeptidase A1, encoded by the CPA1 gene and belongs to the peptidase M14 family. It is a monomeric pancreatic exopeptidase, that catalyzes the release of a C-terminal amino acid, the conversion of leukotriene C4 to leukotriene F4 and is involved in zymogen inhibition. CPA1 is associated with pancreatic cancer susceptibility and implicate ER stress in pancreatic acinar cells in pancreatic cancer development.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

CPA1, CPA

Detailed product information

Technical specifications

CloneREAL1385
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCarboxypeptidase A1
Alternative names of antigenCPA1, CPA
Distribution of antigenpancreatic carcinoma cells, pancreas

Resources for Carboxypeptidase A1 Antibody, anti-human, REAdye_lease™

Certificates

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References for Carboxypeptidase A1 Antibody, anti-human, REAdye_lease™

Publications

  1. Tamura K. et al. (2018) Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer. Proc. Natl. Acad. Sci. U.S.A. 115(18): 4767-4772
  2. Said, S. et al. (2020) Carboxypeptidase A1 and regenerating islet-derived 1α as new markers for pancreatic acinar cell carcinoma. Hum. Pathol. 103: 120-126
  3. Uhlig, R. et al. (2022) Carboxypeptidase A1 (CPA1) Immunohistochemistry Is Highly Sensitive and Specific for Acinar Cell Carcinoma (ACC) of the Pancreas. Am J Surg Pathol 46(1): 97-104

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