Clone:
REA1120
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MICS, IF, IHC
Alternative names:
CDM, CALD1, CAD

Specifications for Caldesmon Antibody, anti-human, REAfinity™

Overview

Clone REA1120 recognizes the human protein Caldesmon, which is a calmodulin binding protein that is involved in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells by inhibiting the ATPase activity of myosin in smooth muscle. It is also implicated in cellular mitosis and receptor capping and plays a role in Schwann cell migration during peripheral nerve regeneration.
Clone REA1120 recognizes the high molecular mass variant of caldesmon (h-caldesmon) and does not react with the non-muscle variant.
Additional information: Clone REA1120 displays negligible binding to Fc receptors.

Alternative names

CDM, CALD1, CAD

Detailed product information

Technical specifications

CloneREA1120
Clonalitymonoclonal
Isotyperecombinant human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCaldesmon
Alternative names of antigenCDM, CALD1, CAD
Molecular mass of antigen [kDa]93
Distribution of antigenSchwann cells, cancer stem cells, smooth muscle
Entrez Gene ID800
RRIDAB_2857444, AB_2857443

References for Caldesmon Antibody, anti-human, REAfinity™

Publications

  1. Huber, P.A. (1997) Caldesmon. Int. J. Biochem. Cell Biol. 29(8-9): 1047-1051
  2. Gusev, N. B. (2001) Some properties of caldesmon and calponin and the participation of these proteins in regulation of smooth muscle contraction and cytoskeleton formation. Biochemistry 66(10): 1112-1121
  3. Horiuchi, K. Y. (1988) Interaction between caldesmon and tropomyosin in the presence and absence of smooth muscle actin. Biochemistry 27(22): 8388-8393

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