Clone:
hC3aRZ8
Type of antibody:
Primary antibodies
Isotype:
mouse IgG2b
Applications:
FC, MICS, IF, IHC
Alternative names:
C3AR1, AZ3B, C3AR, HNFAG09

Specifications for C3a Receptor Antibody, anti-human

Overview

Clone hC3aRZ8 recognizes the human C3a anaphylatoxin chemotactic receptor (C3aR) antigen, a 54 kDa seven transmembrane GTP-binding-protein–coupled receptor which belongs to the rhodopsin supergene family. C3aR is expressed by various cells, including cells of hematopoietic origin such as neutrophils and monocytes, but also non-hematopoietic cells such as renal proximal tubular epithelial cells or neural cells. C3aR functions as a cell surface receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a, a C-terminal 77 amino acid cleavage product of the alpha chain of C3. All cellular responses to C3a are specifically mediated by interactions with the membrane bound C3aR. After C3a binding, the C3aR signaling results in chemotaxis, granule enzyme release, and superoxide anion production. C3aR binding on T cells promotes CD4
+
and CD8
+
T cell activation, proliferation, differentiation, and survival, independently of TCR signals.

Alternative names

C3AR1, AZ3B, C3AR, HNFAG09

Detailed product information

Technical specifications

ClonehC3aRZ8
Clonalitymonoclonal
Isotypemouse IgG2b
Isotype controlIsotype Control Antibody, mouse IgG2b
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenC3a Receptor
Alternative names of antigenC3AR1, AZ3B, C3AR, HNFAG09
Molecular mass of antigen [kDa]54
Distribution of antigenmonocytes, neutrophils
Entrez Gene ID719
RRIDAB_2651298, AB_2651299, AB_2651300, AB_2651301, AB_2651302, AB_2651303, AB_2651304, AB_2651305, AB_2651306, AB_2651307

References for C3a Receptor Antibody, anti-human

Publications

  1. Crass, T. et al. (1996) Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells. Eur. J. Immunol. 26(8): 1944-1950
  2. Ames, R. S. et al. (1996) Molecular cloning and characterization of the human anaphylatoxin C3a receptor. J. Biol. Chem. 271(34): 20231-20234
  3. Gao, J. et al. (2003) Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin. J. Biol. Chem. 278(39): 37902-37908

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