Clone:
REA438
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
BMI1, FLVI2/BMI1, PCGF4, RNF51, flvi-2/bmi-1

Specifications for BMI-1 Antibody, anti-human, REAfinity™

Overview

Clone REA438 recognizes the human B lymphoma Mo-MLV insertion region 1 homolog (BMI-1) antigen, which is also known as polycomb group RING finger protein 4 (PCGF4). BMI-1 is a member of the polycomb group of transcription repressors that was initially identified as an oncogene cooperating with c-myc in a murine model of lymphoma. Both, hematopoietic stem cells (HSCs) and neuronal stem cells, express high levels of BMI-1. It has been shown that BMI-1 is necessary for efficient self-renewing cell divisions of adult HSCs as well as adult peripheral and central nervous system neural stem cells, but that it is less critical for the generation of differentiated progeny. BMI-1 causes neoplastic proliferation when overexpressed in lymphocytes.
Additional information: Clone REA438 displays negligible binding to Fc receptors.

Alternative names

BMI1, FLVI2/BMI1, PCGF4, RNF51, flvi-2/bmi-1

Detailed product information

Technical specifications

CloneREA438
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenBMI-1
Alternative names of antigenBMI1, FLVI2/BMI1, PCGF4, RNF51, flvi-2/bmi-1
Molecular mass of antigen [kDa]37
Distribution of antigenstem cells, hematopoietic stem and progenitor cells
Entrez Gene ID648
RRIDAB_2876919, AB_2876920

References for BMI-1 Antibody, anti-human, REAfinity™

Publications

  1. Park, I. K. et al. (2004) Bmi1, stem cells, and senescence regulation. J. Clin. Invest. 113(2): 175-179
  2. Park, I. K. et al. (2003) Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423(6937): 302-305
  3. Liu, S. et al. (2006) Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res. 66(12): 6063-6071

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