Clone:
REA240
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
AGM4, BASH, BLNK-S, SLP65, bca, Ly-57, Lyw-57

Specifications for BLNK pY84 Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA240 recognizes BLNK protein phosphorylated at tyrosine 84. BLNK is an approximately 50 KDa src homology 2 and 3 domain–containing protein that bears homology to another adaptor molecule called SLP-76 and serves as a central linker/adaptor protein involved in bridging B cell receptor–associated kinase activation with downstream signaling pathways. BLNK is phosphorylated upon BCR stimulation and couples protein tyrosine kinase (PTK) Syk activation to downstream components such as Grb2, Vav, Nck, and phospholipase C (PLC)-γ2. Further, BLNK has been shown to play a role in the activation of all three classes of mitogen-activated protein kinases (MAPKs). Expression of BLNK is found in B cell lineage cells.
Additional information: Clone REA240 displays negligible binding to Fc receptors.

Alternative names

AGM4, BASH, BLNK-S, SLP65, bca, Ly-57, Lyw-57

Detailed product information

Technical specifications

CloneREA240
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
AntigenBLNK pY84
Alternative names of antigenAGM4, BASH, BLNK-S, SLP65, bca, Ly-57, Lyw-57
Distribution of antigenB cells
RRIDAB_2651279, AB_2651280, AB_2651281, AB_2651282, AB_2651283, AB_2651278

References for BLNK pY84 Antibody, anti-human/mouse, REAfinity™

Publications

  1. Baba, Y. et al. (2001) BLNK mediates Syk-dependent Btk activation. Proc. Natl. Acad. Sci. U.S.A. 98: 2582-2586
  2. Wong, J. et al. (2000) Functional complementation of BLNK by SLP-76 and LAT linker proteins. J. Biol. Chem. 275: 33116-33122
  3. Kabak, S. et al. (2002) The direct recruitment of BLNK to immunoglobulin couples the B-cell antigen receptor to distal signaling pathways. Mol. Cell. Biol. 22: 2524-2535

Related products for
BLNK pY84 Antibody, anti-human/mouse, REAfinity™

4 products available

Seems like you are coming from USA!
Do you want to visit our website in your country?