Clone:
REAL864
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
BCL2

Specifications for Bcl-2 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL864 is an antibody fragment derived from the full Bcl-2 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL864 recognizes the human Bcl-2 antigen, which is an intracellular single-pass membrane protein found primarily in the mitochondrion outer membrane, the nucleus membrane, and the endoplasmic reticulum membrane. Bcl-2 is a member of the Bcl-2 family of regulator proteins and forms homodimers or heterodimers with other Bcl-2 family members. It suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Bcl-2 regulates cell death by controlling the mitochondrial membrane permeability and it appears to function in a feedback loop system with caspases. Caspase activity is either inhibited by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor. BCL-2 antibody is suited for the differentiation between reactive and neoplastic follicular proliferation in lymph nodes and could be a useful marker for breast cancer and non-small cell carcinoma of the lung.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

BCL2

Detailed product information

Technical specifications

CloneREAL864
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenBcl-2
Alternative names of antigenBCL2
Distribution of antigenneurons, tonsil

References for Bcl-2 Antibody, anti-human, REAdye_lease™

Publications

  1. Tsujimoto, Y. et al. (1986) Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc. Natl. Acad. Sci. U.S.A. 83(14): 5214-5218
  2. Ciocca, D. R. et al. (2000) Molecular markers for predicting response to tamoxifen in breast cancer patients. Endocrine 13(1): 1-10
  3. Martin, B. et al. (2003) Role of Bcl-2 as a prognostic factor for survival in lung cancer: a systematic review of the literature with meta-analysis. Br. J. Cancer 89(1): 55-64

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