Clone:
REA1140
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MICS, IF, IHC
Alternative names:
CIPER, CLAP, BCL10, mE10, c-E10, cCARMEN

Specifications for Bcl-10 Antibody, anti-human, REAfinity™

Overview

Clone REA1140 recognizes the signaling protein Bcl-10, which is a MALT1 substrate and ubiquitously expressed. Bcl-10, also known as CIPER, CLAP or cCARMEN, plays a role in adaptive immune response. It is able to induce NFκB activation in a NIK-dependent pathway, promotes apoptosis and initiates pro-caspase-9 maturation.
Additional information: Clone REA1140 displays negligible binding to Fc receptors.

Alternative names

CIPER, CLAP, BCL10, mE10, c-E10, cCARMEN

Detailed product information

Technical specifications

CloneREA1140
Clonalitymonoclonal
Isotyperecombinant human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat
Cross-reactivitymouse, rat
AntigenBcl-10
Alternative names of antigenCIPER, CLAP, BCL10, mE10, c-E10, cCARMEN
Molecular mass of antigen [kDa]26
Entrez Gene ID8915
RRIDAB_2857481, AB_2857480

Resources for Bcl-10 Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for Bcl-10 Antibody, anti-human, REAfinity™

Publications

  1. Rebeaud, F. et al. (2008) The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat. Immunol. 9(3): 272-281
  2. Torres, J.M. et al. (2014) Inherited BCL10 deficiency impairs hematopoietic and nonhematopoietic immunity. J. Clin. Invest. 124(12): 5239-5248

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