Clone:
REA887
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Adenomatosis polyposis coli down-regulated 1 protein, DRAPC1, FP7019

Specifications for APCDD1 Antibody, anti-human, REAfinity™

Overview

Clone REA887 recognizes the human APCDD1 antigen, a single-pass type I membrane glycoprotein also known as adenomatosis polyposis coli down-regulated 1 protein or DRAPC1. APCDD1 functions as a negative regulator of the Wnt signaling pathway, is suggested to be involved in colorectal tumorigenesis, and supports the expression and activation of β-catenin. APCDD1 is highly expressed in heart, pancreas, prostate, ovary, and in the epidermal and dermal compartments of the hair follicle. It is moderately expressed in lung, liver, kidney, spleen, thymus, colon, and peripheral lymphocytes.
Additional information: Clone REA887 displays negligible binding to Fc receptors.

Alternative names

Adenomatosis polyposis coli down-regulated 1 protein, DRAPC1, FP7019

Detailed product information

Technical specifications

CloneREA887
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, non-human primate
Cross-reactivity
cynomolgus monkey (
Macaca fascicularis
)
AntigenAPCDD1
Alternative names of antigenAdenomatosis polyposis coli down-regulated 1 protein, DRAPC1, FP7019
Molecular mass of antigen [kDa]56
Distribution of antigenlymphocytes, colon, heart, kidney, liver, lung, ovary, pancreas, spleen
Entrez Gene ID147495
RRIDAB_2726737, AB_2726651, AB_2726738, AB_2726652, AB_2726736, AB_2726650

References for APCDD1 Antibody, anti-human, REAfinity™

Publications

  1. Takahashi, M. et al. (2002) Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis. Cancer Res. 62(20): 5651-5656
  2. Shimomura, Y. et al. (2010) APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex. Nature 464(7291): 1043-1047
  3. Viale-Bouroncle, S. et al. (2015) The WNT inhibitor APCDD1 sustains the expression of β-catenin during the osteogenic differentiation of human dental follicle cells. Biochem. Biophys. Res. Commun. 457(3): 314-317

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