Clone:
REA652
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Alternative names:
TCR a/b, IMD7, TCRA, TRAC, TRB

Specifications for Anti-TCRα/β antibodies

Overview

REA652 recognizes the human α/β T cell receptor (TCR). The T cell receptor is a heterodimer composed of two transmembrane glycoprotein chains, α and β. In 95% of T cells the TCR consists of an α and β chain, whereas in 5% of T cells it has γ and δ chains. α and β chains are members of the Ig superfamily and consist of a constant and a polymorphic variable region. The variable region of the TCRα/β is involved in recognition of antigenic peptides presented by the MHC complex of antigen-presenting cells.
Additional information: Clone REA652 displays negligible binding to Fc receptors.

Alternative names

TCR a/b, IMD7, TCRA, TRAC, TRB

Detailed product information

Technical specifications

CloneREA652
Isotyperecombinant human IgG1
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenTCRα/β
Alternative names of antigenTCR a/b, IMD7, TCRA, TRAC, TRB
Distribution of antigenT cells

Resources for Anti-TCRα/β antibodies

Certificates

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to search for Certificates of Analysis (CoA) by lot number.

References for Anti-TCRα/β antibodies

Publications

  1. Brenner, M. B. et al. (1986) Identification of a putative second T-cell receptor. Nature 322(6075): 145-149
  2. Call, M. E. et al. (2002) The organizing principle in the formation of the T cell receptor-CD3 complex. Cell 111(7): 967-979
  3. Stelzer GT et al. (1997) U.S.-Canadian consensus recommendations on the immunophenotypic analysis of hematologic neoplasia by flow cytometry: standardization and validation of laboratory procedures. Cytometry 30(5): 214-230
  4. Oettgen, H. C. et al. (1984) Characterization of the two heavy chains of the T3 complex on the surface of human T lymphocytes. J. Biol. Chem. 259(19): 12039-12048
  5. Rothe, G et al. (2012) Consensus protocol for the flow cytometric Immunophenotyping of hematopoietic malignancies. Leukemia 10(5): 877-895
  6. van Dongen, J. J. M. et al. (2012) EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes. Leukemia 26(9): 1908-1975
  7. Clinical and Laboratory Standards Institute (CLSI) (2007) Clinical Flow Cytometric Analysis of Neoplastic Hematolympoid Cells, CLSI document H43-A2 (ISBN 1-56238-635-2) CLSI; Approved Guideline - Second Edition
  8. Clinical and Laboratory Standards Institute (CLSI) (2007) Enumeration of immunologically defined cell populations by flow cytometry, CLSI document H42-A2 (ISBN 1-56238-640-9) CLSI; Approved Guideline - Second Edition

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