Anti-Prominin-1 MicroBeads have been developed for the isolation of mouse Prominin-1
+
neural progenitor cells.

Data and images for Anti-Prominin-1 MicroBeads, mouse

Figures

Figure 1

Enrichment of Prominin-1
+
cells from mouse cerebellum (postnatal day 1) using Anti-Prominin-1 MicroBeads, a MiniMACS™ Separator, and MS Columns.
Mouse cerebellar cells before separation
Prominin-1
cells
View details

Figure 1

Enrichment of Prominin-1
+
cells from mouse cerebellum (postnatal day 1) using Anti-Prominin-1 MicroBeads, a MiniMACS™ Separator, and MS Columns.
View details

Figure 1

Enrichment of Prominin-1
+
cells from mouse cerebellum (postnatal day 1) using Anti-Prominin-1 MicroBeads, a MiniMACS™ Separator, and MS Columns.
Prominin-1
+
cells
View details

Figure 1

Enrichment of Prominin-1
+
cells from mouse cerebellum (postnatal day 1) using Anti-Prominin-1 MicroBeads, a MiniMACS™ Separator, and MS Columns.

Specifications for Anti-Prominin-1 MicroBeads, mouse

Overview

Anti-Prominin-1 MicroBeads have been developed for the isolation of mouse Prominin-1
+
neural progenitor cells.

Detailed product information

Background information

Prominin-1 is a glycoprotein with close structural similarity to its human ortholog, CD133
1
. Prominin-1 expression has been demonstrated on cells of different embryonic and adult tissues, including ES-derived committed and early progenitor cells
2
, the developing
3
and postnatal
4
central nervous system, kidney tubules
3
, and cells of the hematopoietic system
3
. In the developing nervous system prominin-1 is predominantly expressed on neuroepithelial cells and other epithelia. In the postnatal brain, prominin-1 expression has been found in areas of neurogenesis, such as the subventricular zone (SVZ). Prominin-1 is preferentially localized to plasma membrane protrusions of the apical membrane.
5

Columns

For positive selection: MS, LS, or autoMACS
®
Columns. For depletion: LD or autoMACS Columns.

References for Anti-Prominin-1 MicroBeads, mouse

Publications

  1. Weigmann, A. et al. (1997) Prominin, a novel microvilli-specific polytopic membrane proteine of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 94: 12425-12430
  2. Kania, G. et al. (2005) Somatic stem cell marker prominin-1/CD133 is expressed in embryonic stem cell-derived progenitors. Stem Cells 23: 791-804
  3. Corbeil, D. et al. (2001) Prominin: a story of cholesterol, plasma membrane protrusions and human pathology. Traffic 2: 82-91
  4. Lee, A. et al. (2005) Isolation of neural stem cells from the postnatal cerebellum. Nat. Neurosci. 8: 723-729
  5. Marzesco, A.-M. et al. (2005) Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells. J. Cell. Sci. 118: 2849-2858

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