Clone:
REA650
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
ADAM 15, MDC-15, MDC15, Metargidin

Specifications for ADAM15 Antibody, anti-human, REAfinity™

Overview

Clone REA650 recognizes the human ADAM15 antigen, a transmembrane protein, which contains disintegrin and metalloprotease domains. ADAM15 belongs to the membrane linked metalloproteinase family (ADAM), which has gelatinolytic and collagenolytic activities. It has several functions, for example, it is involved in wound healing process and in glomerular cell migration. Furthermore ADAM15 suppresses beta-1 integrins-mediated cell adhesion and migration of smooth muscle cells.
Expression of ADAM-15 is found in airway smooth muscle, glomerular mesangial cells, colon, small testine, and chondrocytes. It is highly expressed in atherosclerotic lesions.
Additional information: Clone REA650 displays negligible binding to Fc receptors.

Alternative names

ADAM 15, MDC-15, MDC15, Metargidin

Detailed product information

Technical specifications

CloneREA650
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
Cross-reactivitymouse
AntigenADAM15
Alternative names of antigenADAM 15, MDC-15, MDC15, Metargidin
Molecular mass of antigen [kDa]70
Distribution of antigensmooth muscle
Entrez Gene ID8751
RRIDAB_2651194, AB_2651195, AB_2651196, AB_2651193

References for ADAM15 Antibody, anti-human, REAfinity™

Publications

  1. McKie, N. et al. (1997) Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes. Biochem. Biophys. Res. Commun. 230(2): 335-339
  2. Krätzschmar, J. et al. (1996) Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence. J. Biol. Chem. 271(9): 4593-4596
  3. Zhong, J. L. et al. (2008) Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma. Mol. Cancer Res. 6(3): 383-394

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