Clone:
REAL970
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
cardiac muscle alpha actin, alpha cardiac muscle 1, Alpha-cardiac actin, ACTC

Specifications for ACTC1 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL970 is an antibody fragment derived from the full ACTA1antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL970 recognizes ACTC1, which is also known as cardiac muscle alpha actin or Alpha-cardiac actin. It is an important protein of the thin filament in cardiac sarcomeres, which play a crucial role in muscle contraction and support the pump function of the heart. It belongs to the actin family, highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in eukaryotic cells. Mutations in ACTC1 lead to dilated cardiomyopathy. ACTC1 is considered as a prognostic marker for glioma and for liver metastasis.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

cardiac muscle alpha actin, alpha cardiac muscle 1, Alpha-cardiac actin, ACTC

Detailed product information

Technical specifications

CloneREAL970
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenACTC1
Alternative names of antigencardiac muscle alpha actin, alpha cardiac muscle 1, Alpha-cardiac actin, ACTC
Distribution of antigencardiac cells, muscle

References for ACTC1 Antibody, anti-human, REAdye_lease™

Publications

  1. Olson, T. M. et al. (1998) Actin mutations in dilated cardiomyopathy, a heritable form of heart failure. Science 280(5364): 750-752
  2. Ohtaki, et al. (2017) ACTC1 as an invasion and prognosis marker in glioma. J Neurosurg. 126(2): 467-475
  3. Ingles, J. et al. (2019) Evaluating the Clinical Validity of Hypertrophic Cardiomyopathy Genes. Circ Genom Precis Med 12(2): e002460.
  4. Eun-Kyung, K. et al. (2019) Proteomic Analysis of Primary Colon Cancer and Synchronous Solitary Liver Metastasi. Cancer Genomics Proteomics 16(6): 583-592